Fluorescein Di-β-D-Glucuronide

Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies[1].

Product Specifications

CAS Number

[134869-04-8]

UNSPSC

12171500

Target

Bacterial; β-glucuronidase

Type

Dye Reagents

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fluorescein-di-β-d-glucuronide.html

Purity

96.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1OC2(C3=CC=C(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(O)=O)C=C3OC5=CC(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O)=CC=C52)C7=CC=CC=C71

Molecular Formula

C32H28O17

Molecular Weight

684.55

References & Citations

[1]Michael Chen, et al. Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe. Sci Rep. 2017 Jun 9;7 (1) :3142.