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Finerenone (Standard)

Finerenone (Standard) is the analytical standard of Finerenone. This product is intended for research and analytical applications. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM) . Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold) . Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease[1][2].

Product Specifications

CAS Number

[1050477-31-0]

Product Name Alternative

BAY 94-8862 (Standard)

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Mineralocorticoid Receptor; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/finerenone-standard.html

Purity

99.59

Smiles

O=C(C1=C(C)NC2=C(C(OCC)=NC=C2C)[C@@H]1C3=CC=C(C#N)C=C3OC)N

Molecular Formula

C21H22N4O3

Molecular Weight

378.42

Precautions

H315, H319

References & Citations

[1]Bärfacker L, et al. Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem. 2012;7 (8) :1385-1403.|[2]González-Blázquez R, et al. Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress. Front Pharmacol. 2018;9:1131. Published 2018 Oct 9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

Curated Selection

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