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PfCLK3-IN-1

PfCLK3-IN-1 (Compound 4) is a covalent inhibitor for Plasmodium falciparum CLK3 (Pf CLK3) under alkaline conditions with an pEC50 of 7.1. PfCLK3-IN-1 reduces mature gametocytes in sexual stage parasites, and prevents transmission. PfCLK3-IN-1 inhibits P. falciparum Dd2-B2 clone with an IC50 of 239.5 nM[1].

Product Specifications

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pfclk3-in-1.html

Smiles

O=C(O)C1=CC=C(C2=C3C(NC(C4=CC(CN5CCN(C(CCl)=O)CC5)=CC=C4OC)=C3)=NC=C2)C=C1

Molecular Formula

C28H27ClN4O4

Molecular Weight

518.99

References & Citations

[1]Brettell SB, et al., Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment. J Med Chem. 2024 Nov 14;67 (21) :18895-18910.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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