PfCLK3-IN-1
PfCLK3-IN-1 (Compound 4) is a covalent inhibitor for Plasmodium falciparum CLK3 (Pf CLK3) under alkaline conditions with an pEC50 of 7.1. PfCLK3-IN-1 reduces mature gametocytes in sexual stage parasites, and prevents transmission. PfCLK3-IN-1 inhibits P. falciparum Dd2-B2 clone with an IC50 of 239.5 nM[1].
Product Specifications
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfclk3-in-1.html
Smiles
O=C(O)C1=CC=C(C2=C3C(NC(C4=CC(CN5CCN(C(CCl)=O)CC5)=CC=C4OC)=C3)=NC=C2)C=C1
Molecular Formula
C28H27ClN4O4
Molecular Weight
518.99
References & Citations
[1]Brettell SB, et al., Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment. J Med Chem. 2024 Nov 14;67 (21) :18895-18910.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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