LIN28 inhibitor LI71 enantiomer

LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905) . LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM) . LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM) . LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum[1][2].

Product Specifications

CAS Number

[956189-58-5]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Drug Isomer; MicroRNA; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/lin28-inhibitor-li71-enantiomer.html

Purity

99.68

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C1=CC=C([C@H]2NC3=C(C=CC=C3OCC)[C@]4([H])[C@@]2([H])CC=C4)C=C1

Molecular Formula

C21H21NO3

Molecular Weight

335.40

Precautions

H302, H312, H332

References & Citations

[1]Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018;23 (10) :3091-3101.|[2]Behl A, et al. Targeting an essential Plasmodium cold shock protein to block growth and transmission of malaria parasite. iScience. 2023 Apr 11;26 (5) :106637.