DS06652923

DS06652923 is an orally active EGFR triple mutation inhibitor. DS06652923 has a growth inhibition effect on Ba/F3 EGFR del19/T90M/C797S cells, with a GI50 value of 9.4 nM. DS06652923 can lead to tumor regression in Ba/F3 xenograft models[1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ds06652923.html

Smiles

CC(C)OC1=CC(NC2=CC=NC(C3=CN(S(=O)(C4CC4)=O)N=C3)=N2)=NC=C1C5=CN(C6CCN(C)CC6)N=C5OC(F)F

Molecular Formula

C28H33F2N9O4S

Molecular Weight

629.68

References & Citations

[1]Kageji H, et al. Discovery of a potent, selective, and orally available EGFR C797S mutant inhibitor (DS06652923) with in vivo antitumor activity. Bioorg Med Chem. 2024 Sep 1;111:117862.