Peramivir

Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19[1][2][3].

Product Specifications

CAS Number

[330600-85-6]

Product Name Alternative

RWJ-270201; BCX-1812

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ERK; IKK; JNK; p38 MAPK; STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/peramivir.html

Purity

99.94

Solubility

1 M HCl : 100 mg/mL|DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@]([C@H](C(CC)CC)NC(C)=O)([H])[C@H](NC(N)=N)C[C@@H]1C(O)=O

Molecular Formula

C15H28N4O4

Molecular Weight

328.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang C, et al. Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects [J]. Frontiers in Immunology, 2022, 13: 856327.|[2]Pascua P N Q, et al. Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection [J]. Scientific reports, 2017, 7 (1) : 7345.|[3]Alame M M, et al.. Peramivir: a novel intravenous neuraminidase inhibitor for treatment of acute influenza infections [J]. Frontiers in microbiology, 2016, 7: 450.