NLRP3-IN-41
NLRP3-IN-41 (compd S-9) is an orally active and brain-penetrant NLRP3 inhibitor with anti-inflammatory activities, anti-neuroinflammatory effect and without obvious cytotoxicity. NLRP3-IN-41 inhibits the priming and activation stages of the NLRP3 inflammasome and can be used for inflammasome-related diseases research[1].
Product Specifications
CAS Number
1209698-02-1
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-41.html
Solubility
10 mM in DMSO
Smiles
O=S(N1CCCC2=CC=C(C=C21)NS(=O)(C3=CC=C(C=C3)C4=CC=CC=C4)=O)(C)=O
Molecular Formula
C22H22N2O4S2
Molecular Weight
442.55
References & Citations
[1]Yang F, et al. Identification and Validation of PKR as a Direct Target for the Novel Sulfonamide-Substituted Tetrahydroquinoline Nonselective Inhibitor of the NLRP3 Inflammasome. J Med Chem. 2024 Jun 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
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