Anti-MMP 9 Antibody

Rabbit Polyclonal Antibody specific to MMP9

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

MMP-9, EC 3.4.24.35, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]

Gene Name

MMP9

NCBI Gene ID

UniProt

P14780

Cellular Locus

Secreted, extracellular space, extracellular matrix

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to aa 540-552 of human MMP 9.

Target Antigen

Matrix metalloproteinase-9

Target

MMP 9

Clonality

Polyclonal

Type

Antibody

Applications

Field of Research

Matrix/Metalloproteins

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:2551898, PubMed:1480034, PubMed:12879005). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide. {UniProtKB:P41245, PubMed:12879005, PubMed:1480034, PubMed:2551898, PubMed:32883094}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution. A band at 92 kD is detected.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C to -70°C. Store antibody in appropriate aliquots to avoid multiple freeze-thaw cycles.

Specificity

This antibody specifically recognizes human MMP 9, a matrix metallo- proteinase produced by bone marrow- derived cells and believed to contribute to skin carcinogenesis.