Lucidenic acid O
Lucidenic acid O is a terpene compound, is a DNA polymerases inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and HIV-1 reverse transcriptase with IC50 values of 42 μM, 99 μM, and 69 μM, respectively[1].
Product Specifications
CAS Number
[250643-33-5]
UNSPSC
12352211
Target
DNA/RNA Synthesis; HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lucidenic-acid-o.html
Smiles
C[C@]12C3=C(C(C[C@@]1([C@H](C[C@@H]2O)C(CCC(O)=O)=C)C)=O)[C@@]4([C@@]([C@@](C)([C@H](CC4)O)CO)([H])C[C@@H]3O)C
Molecular Formula
C27H40O7
Molecular Weight
476.60
References & Citations
[1]Mizushina Y, et al. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. Bioorg Med Chem. 1999 Sep;7 (9) :2047-52.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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