Lucidenic acid O

Lucidenic acid O is a terpene compound, is a DNA polymerases inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and HIV-1 reverse transcriptase with IC50 values of 42 μM, 99 μM, and 69 μM, respectively[1].

Product Specifications

CAS Number

[250643-33-5]

UNSPSC

12352211

Target

DNA/RNA Synthesis; HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lucidenic-acid-o.html

Smiles

C[C@]12C3=C(C(C[C@@]1([C@H](C[C@@H]2O)C(CCC(O)=O)=C)C)=O)[C@@]4([C@@]([C@@](C)([C@H](CC4)O)CO)([H])C[C@@H]3O)C

Molecular Formula

C27H40O7

Molecular Weight

476.60

References & Citations

[1]Mizushina Y, et al. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. Bioorg Med Chem. 1999 Sep;7 (9) :2047-52.