BayCysLT2

BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC50 value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts[1][2].

Product Specifications

CAS Number

[712313-33-2]

UNSPSC

12352005

Target

Leukotriene Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/baycyslt2.html

Purity

97.7

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

OC(C1=CC=C(OCCCC2=CC=C(C=C2)OCCCCOC3=CC=CC=C3)C(C(NC4CC(C(O)=O)CCC4)=O)=C1)=O

Molecular Formula

C34H39NO8

Molecular Weight

589.68

References & Citations

[1]Michael Harter, et al. Isophtalic acid derivatives. US20060154912A1. 2009 March 03.|[2]Ni NC, et al. A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. J Pharmacol Exp Ther. 2011 Dec;339 (3) :768-78.