Hh-Ag1.5

Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM[1]. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure[2].

Product Specifications

CAS Number

[612542-14-0]

Product Name Alternative

SAg1.5

UNSPSC

12352005

Target

Hedgehog

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hh-ag1-5.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(SC1=C(C=C2)F)=C(C1=C2F)Cl)N([C@@H](CC3)CC[C@H]3NC)CC4=CC(C5=CC=NC=C5)=CC=C4

Molecular Formula

C28H26ClF2N3OS

Molecular Weight

526.04

References & Citations

[1]Randall W King. Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling. J Biol. 2002 Nov 6;1 (2) :8.|[2]Abhisek Mitra, et al. A Small Molecule Hedgehog Agonist HhAg1.5 Mediated Reprogramming Breaks the Quiescence of Noninjured Liver Stem Cells for Rescuing Liver Failure. Transl Res. 2019 Mar;205:44-50.|[3]Maria Frank-Kamenetsky, et al. Small-molecule Modulators of Hedgehog Signaling: Identification and Characterization of Smoothened Agonists and Antagonists. J Biol. 2002 Nov 6;1 (2) :10.|[4]Cynthia M Rominger, et al. Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor. J Pharmacol Exp Ther. 2009 Jun;329 (3) :995-1005.