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Dexamethasone (GMP)

Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor[1][2][3][4].

Product Specifications

CAS Number

[50-02-2]

Product Name Alternative

Hexadecadrol (GMP) ; Prednisolone F (GMP)

UNSPSC

12352211

Hazard Statement

H334, H360, H373, H410

Target

ADC Payload; Glucocorticoid Receptor

Type

GMP Small Molecules

Related Pathways

Antibody-drug Conjugate/ADC Related; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dexamethasone-gmp.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C[C@]2(C(CC[C@@]3([C@@]2([C@H](C[C@]4([C@]3(C[C@H]([C@]4(O)C(CO)=O)C)[H])C)O)F)[H])=C1)C

Molecular Formula

C22H29FO5

Molecular Weight

392.46

Precautions

H334, H360, H373, H410

References & Citations

[1]Grigoriadis AE, et al. Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. J Cell Biol. 1988 Jun;106 (6) :2139-51.|[2]Tenenbaum HC, Heersche JN. Dexamethasone stimulates osteogenesis in chick periosteum in vitro. Endocrinology. 1985 Nov;117 (5) :2211-7.|[3]Rickard DJ, et al. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol. 1994 Jan;161 (1) :218-28.|[4]Alliot-Licht B, et al. Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures. Cell Tissue Res. 2005 Sep;321 (3) :391-400.

Shipping Conditions

Blue Ice

Storage Conditions

RT, sealed storage, away from moisture and light

Scientific Category

GMP Small Molecules

Clinical Information

No Development Reported

Citation 01

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