BmP02
Product Specifications
UNSPSC Description
BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells[1][2].
Target Antigen
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bmp02.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(NCC(N[C@H]1C(C)C)=O)=O)=O)=O)NC2=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]3CC(N)=O)=O)NC1=O)C(N4[C@@H](CCC4)C(N[C@@H](CCSC)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)NC3=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N[C@H]2[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Molecular Weight
2949.35
References & Citations
[1]Wu B, et al. Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel. Sci Rep. 2016 Jul 11;6:29431.|[2]Wu B, et al. BmP02 Atypically Delays Kv4.2 Inactivation: Implication for a Unique Interaction between Scorpion Toxin and Potassium Channel. Toxins (Basel). 2016 Sep 27;8(10):280.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5157/BmP02-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5157/
Clinical Information
No Development Reported
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