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BmP02

BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC50 value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells[1][2].

Product Specifications

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bmp02.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(NCC(N[C@H]1C(C)C)=O)=O)=O)=O)NC2=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]3CC(N)=O)=O)NC1=O)C(N4[C@@H](CCC4)C(N[C@@H](CCSC)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)NC3=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N[C@H]2[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

Molecular Formula

C115H182N36O41S7

Molecular Weight

2949.35

References & Citations

[1]Wu B, et al. Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel. Sci Rep. 2016 Jul 11;6:29431.|[2]Wu B, et al. BmP02 Atypically Delays Kv4.2 Inactivation: Implication for a Unique Interaction between Scorpion Toxin and Potassium Channel. Toxins (Basel) . 2016 Sep 27;8 (10) :280.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P5157/BmP02-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P5157/

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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