AC-42 (hydrochloride)

AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806) . AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP) -accumulation and calcium mobilization in CHO cells[1][2].

Product Specifications

CAS Number

[447407-36-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ac-42-hydrochloride.html

Purity

98.42

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1C)CCCN2CCC(CCCC)CC2.[H]Cl

Molecular Formula

C20H32ClNO

Molecular Weight

337.93

Precautions

H302, H315, H319, H335

References & Citations

[1]Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'- (2-methylbenzyl) -1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78 (4) :648-57.|[2]Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4- (2-methylphenyl) -4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M (1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69 (1) :236-46.