LY2365109
Product Specifications
UNSPSC Description
LY2365109 is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a[1][2].
Target Antigen
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly2365109.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C
Molecular Weight
385.45
References & Citations
[1]Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54. |[2]Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100416/LY2365109-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100416/
Clinical Information
No Development Reported
CAS Number
868265-28-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6460324-01 0.1 mL
ZBTB7C (Zinc Finger and BTB Domain-Containing Protein 7C, Affected by papillomavirus DNA integration in ME180 Cells Protein 1, APM-1, Zinc Finger and BTB Domain-Containing Protein 36, Zinc Finger Protein 857C, ZBTB7C, APM1, ZBTB36, ZNF857C) (HRP)
Ask
View Details