Lonodelestat

Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE) . Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) [1][2][3].

Product Specifications

CAS Number

[906547-89-5]

Product Name Alternative

POL6014

UNSPSC

12352209

Target

Elastase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lonodelestat.html

Purity

99.59

Solubility

H2O : 20 mg/mL (ultrasonic; warming)

Smiles

O=C(N(CCC1)[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H]2CO)=O)C)=O)([H])[C@H](O)C)=O)CCC(O)=O)=O)CCCCCCCC)=O)[C@](CCC3)([H])N3C([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CCC4)([H])N4C([C@@](CCC5)([H])N5C([C@](NC2=O)([H])[C@@H](C)CC)=O)=O)=O)CCC(N)=O)=O)CCCCN)=O)CC(C=C6)=CC=C6O)=O

Molecular Formula

C71H111N15O19

Molecular Weight

1478.73

References & Citations

[1]Lagente V, et al. A novel Protein Epitope Mimetic (PEM) neutrophil elastase (NE) inhibitor, POL6014, inhibits human NE-induced acute lung injury in mice. ATS, San Diego, May 15-20, 2009.|[2]Odile Sellier-Kessler, et al. Inhibition of lung inflammation by a protein epitope mimetic (PEM) neutrophil elastase inhibitor, POL6014, in a sub-chronic tobacco smoke (TS) model in mice. European Respiratory Journal 2013 42: 1762.|[3]Barth P, et al. Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis. J Cyst Fibros. 2020 Mar;19 (2) :299-304.