Kininogen (HMWK) from Human Plasma

<strong>Kininogen (HMWK) from Human Plasma</strong>_x000D_ <strong>Catalog number:</strong> B2012163_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 120 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Williams-Fitzgerald-Flaujeac factor, HMWK-kallikrein factor, HK_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Köhler J, Maletzki C, Koczan D, Frank M, Springer A, Steffen C, Revenko AS, MacLeod AR, Mikkat S, Kreikemeyer B, Oehmcke-Hecht S. Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis EBioMedicine. 2020 Aug;58:102908._x000D_ 2: Ponczek MB. High Molecular Weight Kininogen: A Review of the Structural Literature Int J Mol Sci. 2021 Dec 13;22(24):13370._x000D_ 3: Schmaier AH, Smith PM, Purdon AD, White JG, Colman RW. High molecular weight kininogen: localization in the unstimulated and activated platelet and activation by a platelet calpain(s) Blood. 1986 Jan;67(1):119-30._x000D_ 4: Schmaier AH, Bradford H, Silver LD, Farber A, Scott CF, Schutsky D, Colman RW. High molecular weight kininogen is an inhibitor of platelet calpain J Clin Invest. 1986 May;77(5):1565-73._x000D_ 5: Schmaier AH, Kuo A, Lundberg D, Murray S, Cines DB. The expression of high molecular weight kininogen on human umbilical vein endothelial cells J Biol Chem. 1988 Nov 5;263(31):16327-33._x000D_ 6: Schmaier AH, Schutsky D, Farber A, Silver LD, Bradford HN, Colman RW. Determination of the bifunctional properties of high molecular weight kininogen by studies with monoclonal antibodies directed to each of its chains J Biol Chem. 1987 Jan 25;262(3):1405-11._x000D_ 7: Gustafson EJ, Schutsky D, Knight LC, Schmaier AH. High molecular weight kininogen_ binds to unstimulated platelets J Clin Invest. 1986 Jul;78(1):310-8._x000D_ 8: Omata K. [Laboratory values of kallikrein-kininogen-kinin] Nihon Rinsho. 2005 Aug;63 Suppl 8:573-6._x000D_ 9: Hofman ZLM, De Maat S, Maas C. High-molecular-weight kininogen: breaking bad in lethal endotoxemia J Thromb Haemost. 2018 Feb;16(2):193-195._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/6695362">10: Schmaier AH, Silver L, Adams AL, Fischer GC, Munoz PC, Vroman L, Colman RW. The effect of high molecular weight kininogen on surface-adsorbed fibrinogen Thromb Res. 1984 Jan 1;33(1):51-67. </a>_x000D_ _x000D_ <strong>Products Related to Kininogen (HMWK) from Human Plasma can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>