Talotrexin

Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].

Product Specifications

CAS Number

[113857-87-7]

Product Name Alternative

PT523

UNSPSC

12352005

Target

Antifolate; Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/talotrexin.html

Purity

99.27

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2

Molecular Formula

C27H27N9O6

Molecular Weight

573.56

References & Citations

[1]O'Connor C, et al. Folate transporter dynamics and therapy with classic and tumor-targeted antifolates. Sci Rep. 2021 Mar 18;11 (1) :6389.|[2]Choy G S, et al. Combination talotrexin (PT-523) with paclitaxel in A549 non-small cell lung cancer (NSCLC) athymic nude mice xenografts[J]. Cancer Research, 2007, 67 (1_Annual_Meeting) .