3-ATA

3-ATA (NSC 680434) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) with neuroprotective and antitumor effects. 3-ATA can alleviate kainic acid (HY-N2309) -induced apoptosis in cerebellar granule neurons, which can be used in the study of neurodegenerative diseases[1].

Product Specifications

CAS Number

[129821-08-5]

Product Name Alternative

NSC 680434

UNSPSC

12352005

Target

Apoptosis; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-ata.html

Smiles

S=C1C2=C(C=CC=C2)NC3=CC(N)=CC=C13

Molecular Formula

C13H10N2S

Molecular Weight

226.30

References & Citations

[1]Verdaguer E, et al. 3-Amino thioacridone, a selective cyclin-dependent kinase 4 inhibitor, attenuates kainic acid-induced apoptosis in neurons[J]. Neuroscience, 2003, 120 (3) : 599-603.