3-ATA
3-ATA (NSC 680434) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) with neuroprotective and antitumor effects. 3-ATA can alleviate kainic acid (HY-N2309) -induced apoptosis in cerebellar granule neurons, which can be used in the study of neurodegenerative diseases[1].
Product Specifications
CAS Number
[129821-08-5]
Product Name Alternative
NSC 680434
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3-ata.html
Smiles
S=C1C2=C(C=CC=C2)NC3=CC(N)=CC=C13
Molecular Formula
C13H10N2S
Molecular Weight
226.30
References & Citations
[1]Verdaguer E, et al. 3-Amino thioacridone, a selective cyclin-dependent kinase 4 inhibitor, attenuates kainic acid-induced apoptosis in neurons[J]. Neuroscience, 2003, 120 (3) : 599-603.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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