Nilvadipine

Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.

Product Specifications

CAS Number

[75530-68-6]

Product Name Alternative

FK235; FR34235

UNSPSC

12352005

Hazard Statement

H302

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nilvadipine.html

Purity

99.71

Solubility

DMSO : ≥ 50 mg/mL

Smiles

COC(C1=C(C#N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2)=O

Molecular Formula

C19H19N3O6

Molecular Weight

385.37

Precautions

H302

References & Citations

[1]Nomoto A, et al. Smooth muscle cell migration induced by inflammatory cell products and its inhibition by a potent calcium antagonist, Nilvadipine. Atherosclerosis. 1988 Aug;72 (2-3) :213-9.|[2]Nomoto A, et al. Antiatherogenic activity of FR34235 (Nilvadipine), a new potent calcium antagonist. Effect on cuff-induced intimal thickening of rabbit carotid artery. Atherosclerosis. 1987 Apr;64 (2-3) :255-61.|[3]Sugawara H, et al. Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation. Hypertens Res. 1996 Dec;19 (4) :223-8.|[4]Yamazaki H, et al. Preservation of retinal morphology and functions in royal college surgeons rat by Nilvadipine, a Ca (2+) antagonist. Invest Ophthalmol Vis Sci. 2002 Apr;43 (4) :919-26.