Nilvadipine
Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
Product Specifications
CAS Number
75530-68-6
Product Name Alternative
FK235; FR34235
UNSPSC
12352005
Hazard Statement
H302
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nilvadipine.html
Purity
99.71
Solubility
DMSO : ≥ 50 mg/mL
Smiles
COC(C1=C(C#N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2)=O
Molecular Formula
C19H19N3O6
Molecular Weight
385.37
Precautions
H302
References & Citations
[1]Nomoto A, et al. Smooth muscle cell migration induced by inflammatory cell products and its inhibition by a potent calcium antagonist, Nilvadipine. Atherosclerosis. 1988 Aug;72 (2-3) :213-9.|[2]Nomoto A, et al. Antiatherogenic activity of FR34235 (Nilvadipine), a new potent calcium antagonist. Effect on cuff-induced intimal thickening of rabbit carotid artery. Atherosclerosis. 1987 Apr;64 (2-3) :255-61.|[3]Sugawara H, et al. Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation. Hypertens Res. 1996 Dec;19 (4) :223-8.|[4]Yamazaki H, et al. Preservation of retinal morphology and functions in royal college surgeons rat by Nilvadipine, a Ca (2+) antagonist. Invest Ophthalmol Vis Sci. 2002 Apr;43 (4) :919-26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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