Guanylin (Human)

<strong>Guanylin (Human)</strong> <strong>Catalog number:</strong> MDP0646 <strong>CAS Number: </strong>284466-15-5 <strong>Sequence: </strong>Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys (Disulfide bonds between Cys4-Cys12 and Cys7-Cys15) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 1458.4 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Busslinger GA, Weusten BLA, Bogte A, Begthel H, Brosens LAA, Clevers H. Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution Cell Rep. 2021 Mar 9;34(10):108819. 2: Forte LR, Eber SL, Turner JT, Freeman RH, Fok KF, Currie MG. Guanylin stimulation of Cl- secretion in human intestinal T84 cells via cyclic guanosine monophosphate J Clin Invest. 1993 Jun;91(6):2423-8. 3: Wiegand RC, Kato J, Huang MD, Fok KF, Kachur JF, Currie MG. Human guanylin: cDNA isolation, structure, and activity FEBS Lett. 1992 Oct 19;311(2):150-4. 4: Rodríguez A, Gómez-Ambrosi J, Catalán V, Ezquerro S, Méndez-Giménez L, Becerril S, Ibáñez P, Vila N, Margall MA, Moncada R, Valentí V, Silva C, Salvador J, Frühbeck G. Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes Int J Obes (Lond). 2016 Sep;40(9):1405-15. 5: Kulaksiz H, Schlenker T, Rost D, Stiehl A, Volkmann M, Lehnert T, Cetin Y, Stremmel W. Guanylin regulates chloride secretion in the human gallbladder via the bile fluid Gastroenterology. 2004 Mar;126(3):732-40. 6: Kulaksiz H, Schmid A, Hönscheid M, Eissele R, Klempnauer J, Cetin Y. Guanylin in the human pancreas: a novel luminocrine regulatory pathway of electrolyte secretion via cGMP and CFTR in the ductal system Histochem Cell Biol. 2001 Feb;115(2):131-45. 7: Steinbrecher KA, Tuohy TM, Heppner Goss K, Scott MC, Witte DP, Groden J, Cohen MB. Expression of guanylin is downregulated in mouse and human intestinal adenomas Biochem Biophys Res Commun. 2000 Jun 24;273(1):225-30. 8: Kita T, Smith CE, Fok KF, Duffin KL, Moore WM, Karabatsos PJ, Kachur JF, Hamra FK, Pidhorodeckyj NV, Forte LR, et al. Characterization of human uroguanylin: a member of the guanylin peptide family Am J Physiol. 1994 Feb;266(2 Pt 2):F342-8. 9: Brenna Ø, Furnes MW, Munkvold B, Kidd M, Sandvik AK, Gustafsson BI. Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa Cell Tissue Res. 2016 Aug;365(2):331-41. <a href="https://pubmed.ncbi.nlm.nih.gov/11596856">10: Bełtowski J. Guanylin and related peptides J Physiol Pharmacol. 2001 Sep;52(3):351-75.</a> <br><strong>Products Related to Guanylin (Human) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>