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GSK 366

GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50s of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO), respectively[1].

Product Specifications

CAS Number

1953157-39-5

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk-366.html

Purity

99.80

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)CCC1=NOC2=C1C=C(Cl)C(O[C@@H](C3=NN=C(C)C=C3)C)=C2

Molecular Formula

C17H16ClN3O4

Molecular Weight

361.78

References & Citations

[1]Hutchinson JP, et al. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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