SGC-GAK-1
SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK[1].
Product Specifications
CAS Number
[2226517-76-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cyclin G-associated Kinase (GAK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SGC-GAK-1.html
Purity
99.92
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
COC1=C(C(OC)=CC(NC2=CC=NC3=CC=C(C=C23)Br)=C1)OC
Molecular Formula
C18H17BrN2O3
Molecular Weight
389.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Asquith CRM, et al. SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK) . J Med Chem. 2019 Feb 26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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