Semustine
Semustine is a DNA alkylator, binds to DNA, and acts as a cancer chemotherapeutic agent[1].
Product Specifications
CAS Number
[13909-09-6]
UNSPSC
12352211
Hazard Statement
H300, H311+H331, H315, H319, H335, H350, H360
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/semustine.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1CCC(C)CC1)N(CCCl)N=O
Molecular Formula
C10H18ClN3O2
Molecular Weight
247.72
Precautions
H300, H311+H331, H315, H319, H335, H350, H360
References & Citations
[1]Agarwal S, et al. Molecular modeling and spectroscopic studies of semustine binding with DNA and its comparison with lomustine-DNA adduct formation. J Biomol Struct Dyn. 2015;33 (8) :1653-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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