PROTAC AKR1C3 degrader-1
PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647) ; Pink: AKR1C3 inhibitor (HY-163610) ) [1].
Product Specifications
UNSPSC
12352005
Target
Aldose Reductase; PROTACs
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-akr1c3-degrader-1.html
Smiles
O=C(/C=C/C1=CC(C2=CC=CC=C2)=CC(C(NCC3=CC=C(C=C3)OCC4=CN(N=N4)CCOCCOCC(NC5=CC=CC6=C5CN(C6=O)C7CCC(NC7=O)=O)=O)=O)=C1)O
Molecular Formula
C45H43N7O10
Molecular Weight
841.86
References & Citations
[1]Carmona AV, et al. Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader. Commun Chem. 2024 Apr 29;7 (1) :95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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