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PROTAC AKR1C3 degrader-1

PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647) ; Pink: AKR1C3 inhibitor (HY-163610) ) [1].

Product Specifications

UNSPSC

12352005

Target

Aldose Reductase; PROTACs

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-akr1c3-degrader-1.html

Smiles

O=C(/C=C/C1=CC(C2=CC=CC=C2)=CC(C(NCC3=CC=C(C=C3)OCC4=CN(N=N4)CCOCCOCC(NC5=CC=CC6=C5CN(C6=O)C7CCC(NC7=O)=O)=O)=O)=C1)O

Molecular Formula

C45H43N7O10

Molecular Weight

841.86

References & Citations

[1]Carmona AV, et al. Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader. Commun Chem. 2024 Apr 29;7 (1) :95.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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