GW 441756

GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth[1][2][3].

Product Specifications

CAS Number

[504433-23-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Trk Receptor

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/GW-441756.html

Purity

99.85

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C1/C(C2=NC=CC=C2N1)=C\C3=CN(C)C4=C3C=CC=C4

Molecular Formula

C17H13N3O

Molecular Weight

275.30

Precautions

H315, H319, H335

References & Citations

[1]Zhao F, et al. BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion Buthus martensii Karsch, Promotes Neurite Outgrowth via NGF/TrkA Signaling Pathway. Toxins (Basel) . 2021;13 (1) :33. Published 2021 Jan 5.|[2]Terada K, et al. Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors. PLoS One. 2018;13 (12) :e0209250. Published 2018 Dec 17.|[3]Wood ER, et al. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004;14 (4) :953-957.