Luzopeptin A

Luzopeptin A (BBM-928 A) is an actinoleukin-like antitumor antibiotic. Luzopeptin A is a bifunctional DNA intercalator which can interact with isolated DNA molecules. Luzopeptin A induces an unwinding-rewinding process of the closed superhelical PM2 DNA. Luzopeptin A is active against HIV-1 and HIV-2 reverse transcriptase with IC50s of 7 nM and 68 nM for HIV-1 RT and HIV-2 RT, respectively[1][2].

Product Specifications

CAS Number

[75580-37-9]

Product Name Alternative

BBM-928 A

UNSPSC

12352005

Target

Antibiotic; HIV

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/luzopeptin-a.html

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@@](C(NCC(N(CC(N([C@H](C(OC[C@H](C(N3[C@]([C@H](CC=N3)OC(C)=O)([H])C(NCC(N(CC(N([C@H](C(OC[C@H]1NC(C4=NC5=C(C=C(C=C5)OC)C=C4O)=O)=O)C(C)(O)C)C)=O)C)=O)=O)=O)NC(C6=NC7=C(C=C(C=C7)OC)C=C6O)=O)=O)C(C)(O)C)C)=O)C)=O)=O)([H])[C@H](CC=N2)OC(C)=O

Molecular Formula

C64H78N14O24

Molecular Weight

1427.38

References & Citations

[1]Konishi M, Ohkuma H, Sakai F, et al. Structures of BBM-928 A, B, and C. Novel antitumor antibiotics from Actinomadura luzonensis[J]. Journal of the American Chemical Society, 1981, 103 (5) : 1241-1243.