Cefazolin (sodium)

Cefazolin sodium is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin sodium has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD) [2].

Product Specifications

CAS Number

[27164-46-1]

Product Name Alternative

Cephazolin (sodium)

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Cefazolin-sodium.html

Purity

98.45

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(C(N12)=C(CSC3=NN=C(C)S3)CS[C@]2([H])[C@H](NC(CN4N=NN=C4)=O)C1=O)O[Na]

Molecular Formula

C14H13N8NaO4S3

Molecular Weight

476.49

Precautions

H317, H334

References & Citations

[1]R Quintiliani, et al. Cefazolin. Ann Intern Med. 1978 Nov;89 (5 Pt 1) :650-6.|[2]Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15 (1) :235.|[3]Barbara Żyżyńska-Granica, et al. The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor. Sci Rep. 2020 Feb 19;10 (1) :2886.