AG14361

AG14361 is a potent PARP-1 inhibitor, with a Ki of IC50s are 29 nM and 14 nM, respectively.

Product Specifications

CAS Number

[328543-09-5]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AG14361.html

Concentration

10mM

Purity

99.44

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NCCN2C3=C1C=CC=C3N=C2C4=CC=C(C=C4)CN(C)C

Molecular Formula

C19H20N4O

Molecular Weight

320.39

References & Citations

[1]Calabrese CR, et al. Anticancer chemosensitization and radiosensitization by the novel poly (ADP-ribose) polymerase-1 inhibitor AG14361. J Natl Cancer Inst. 2004 Jan 7;96 (1) :56-67.|[2]Vazquez-Ortiz G, et al. Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells. Breast Cancer Res. 2014 Jun 24;16 (3) :R67.|[3]Smith LM, et al. The novel poly (ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. Clin Cancer Res. 2005 Dec 1;11 (23) :8449-57.