SB-414796

SB-414796 is a selective, orally active and cross the blood-brain barrier dopamine D3 receptor antagonist with Ki values of 4, 400 nM for D3, D2, respectively[1][2].

Product Specifications

CAS Number

[264262-71-7]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-414796.html

Smiles

CS(C1=CC2=C(C=C1)CCN(CC2)CC[C@H]3CC[C@@H](CC3)NC(C4=CC=CC(C5=NOC(C)=N5)=C4)=O)(=O)=O

Molecular Formula

C29H36N4O4S

Molecular Weight

536.69

References & Citations

[1]Macdonald GJ, et al. Design and synthesis of trans-3- (2- (4- ((3- (3- (5-methyl-1,2,4-oxadiazolyl) ) - phenyl) carboxamido) cyclohexyl) ethyl) -7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796) : a potent and selective dopamine D3 receptor antagonist. J Med Chem. 2003 Nov 6;46 (23) :4952-64.|[2]Heidbreder CA, et al. Current perspectives on selective dopamine D (3) receptor antagonists as pharmacotherapeutics for addictions and related disorders. Ann N Y Acad Sci. 2010 Feb;1187:4-34.