DNA Polymerase lambda Recombinant Rabbit Monoclonal Antibody [PSH05-24]
DNA polymerase lambda, also known as Pol λ, is an enzyme found in all eukaryotes. In humans, it is encoded by the POLL gene. Pol λ is a member of the X family of DNA polymerases. It is thought to resynthesize missing nucleotides during non-homologous end joining (NHEJ), a pathway of DNA double-strand break (DSB) repair. NHEJ is the main pathway in higher eukaryotes for repair of DNA DSBs. Chromosomal DSBs are the most severe type of DNA damage. During NHEJ, duplexes generated by the alignment of broken DNA ends usually contain small gaps that need to be filled in by a DNA polymerase. DNA polymerase lambda can perform this function.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
POLL
Swiss Prot
Q9UGP5 Human, Q9QXE2 Mouse
Cellular Locus
Nucleus, Chromosome.
Host
Rabbit
Species Reactivity
Human,Mouse,Monkey
Immunogen
Recombinant protein within human DNA Polymerase lambda aa 1-575 / 575.
Isotype
IgG
Clone
PSH05-24
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
HeLa cell lysate, A549 cell lysate, 293T cell lysate, HepG2 cell lysate, mouse testis tissue lysate, COS-1 cell lysate, human testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 63 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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