AChE/BChE-IN-18
AChE/BChE-IN-18 (Compound 4g) is a dual inhibitor of AChE/BChE , with a IC50 value of 0.315 μM for AchE. AChE/BChE-IN-18 is also a CB2R antagonist with a Ki value of 31 nM. AChE/BChE-IN-18 has neuroprotective activity[1].
Product Specifications
UNSPSC
12352005
Target
Cannabinoid Receptor; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bche-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C)C)OC1=CC(CN2CC(SC(NC(C3(C4)C[C@H]5C[C@H](C[C@@H]4C5)C3)=O)=C6C(OC)=O)=C6CC2)=CC=C1
Molecular Formula
C30H37N3O5S
Molecular Weight
551.70
References & Citations
[1]Mugnaini C, et al. Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo. ACS Chem Neurosci. 2024 Feb 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; CB2
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