4-Methylbenzylidene camphor

4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy[1][2].

Product Specifications

CAS Number

[36861-47-9]

Product Name Alternative

4-MBC; Enzacamene

UNSPSC

12352005

Hazard Statement

H361

Target

Akt; Apoptosis; ERK; PI3K

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-Methylbenzylidene-camphor.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

CC1(C)[C@@H]2CC[C@]1(C)C(/C2=C\C3=CC=C(C)C=C3)=O

Molecular Formula

C18H22O

Molecular Weight

254.37

Precautions

H361

References & Citations

[1]Changwon Yang, et al. 4-Methylbenzylidene-camphor inhibits proliferation and induces reactive oxygen species-mediated apoptosis of human trophoblast cells. Reprod Toxicol. 2019 Mar:84:49-58.|[2]Margret Schlumpf, et al. Developmental toxicity of UV filters and environmental exposure: a review. Int J Androl. 2008 Apr;31 (2) :144-51.