GITR / Tnfrsf18 (Mouse) (DTA-1), 0.2mg/mL

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Product Specifications

CAS Number

9007-83-4

Synonyms

Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

TNFRSF18

Gene ID

21936

NCBI Gene ID

3180

UniProt

O35714

Swiss Prot

O35714

Host

Rat

Species Reactivity

Mouse

Reactivity

GITR|Tnfrsf18

Immunogen

Mouse CD25 CD4 T cells

Target Antigen

GITR | Tnfrsf18

Clonality

Monoclonal

Clone

DTA-1

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |Functional studies (published)

Field of Research

Immunology, Inflammation

Positive Control

CD25 CD4 Tregs.

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

66-70 kDa (Homodimer)

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Clin Cancer Res (2013) 19(5): 1044-53. (functional studies) J Immunol (2019) 203:864-872. (Flow)