Prosaptide Tx14 (A)

Prosaptide Tx14 (A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14 (A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].

Product Specifications

CAS Number

[196391-82-9]

UNSPSC

12352209

Target

Orphan Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/prosaptide-tx14-a.html

Purity

99.51

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@@H](C)NC([C@@H](N)[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C69H110N16O26

Molecular Weight

1579.70

References & Citations

[1]Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110 (23) :9529-9534.|[2]Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12 (3) :307-314.