Aminoacyl tRNA synthetase-IN-1

Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor. Aminoacyl tRNA synthetase-IN-1 has inhibitory activity against S. aureus, E. faecalis and E.coli[1].

Product Specifications

CAS Number

[219931-45-0]

Product Name Alternative

IleSA

UNSPSC

12352005

Target

Aminoacyl-tRNA Synthetase; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Aminoacyl_tRNA_synthetase-IN-1.html

Purity

99.80

Solubility

DMSO : 65 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](COS(=O)(NC([C@H]([C@@H](C)CC)N)=O)=O)O[C@@H](N2C(N=CN=C3N)=C3N=C2)[C@@H]1O

Molecular Formula

C16H25N7O7S

Molecular Weight

459.48

References & Citations

[1]Vondenhoff GH, et al. Microcin C and albomycin analogues with aryl-tetrazole substituents as nucleobase isosters areselective inhibitors of bacterial aminoacyl tRNA synthetases but lack efficient uptake. Chembiochem. 2012 Sep 3;13 (13) :1959-69.