PRMT5-MTA-IN-1
PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor for protein arginine methyltransferase PRMT5-MTA. PRMT5-MTA-IN-1 inhibits the proliferation of colorectal cancer cell HCT116 wildtype and MTAP del mutant, with an IC50 of 16 nM and 2.47 μM. PRMT5-MTA-IN-1 exhibits good liver microsomal stability and film permeability. PRMT5-MTA-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mice[1].
Product Specifications
CAS Number
3048425-88-0
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-mta-in-1.html
Smiles
CC1=C(C(N)=NC2=CC(F)=C(C=C21)C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C)=O)CO
Molecular Formula
C22H19F4N3O3
Molecular Weight
449.40
References & Citations
[1]Liu B et al., PRMT5-MTA inhibitors. CN118271307A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
Frequently Asked Questions
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