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PRMT5-MTA-IN-1

PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor for protein arginine methyltransferase PRMT5-MTA. PRMT5-MTA-IN-1 inhibits the proliferation of colorectal cancer cell HCT116 wildtype and MTAP del mutant, with an IC50 of 16 nM and 2.47 μM. PRMT5-MTA-IN-1 exhibits good liver microsomal stability and film permeability. PRMT5-MTA-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mice[1].

Product Specifications

CAS Number

3048425-88-0

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prmt5-mta-in-1.html

Smiles

CC1=C(C(N)=NC2=CC(F)=C(C=C21)C(N([C@@H]3COC4=CC(C(F)(F)F)=CC=C43)C)=O)CO

Molecular Formula

C22H19F4N3O3

Molecular Weight

449.40

References & Citations

[1]Liu B et al., PRMT5-MTA inhibitors. CN118271307A.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT5

Frequently Asked Questions

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