11 ß-HSD1 CRISPR/Cas9 KO Plasmid

<strong>11 ß-HSD1 CRISPR/Cas9 KO Plasmid</strong>_x000D_ <strong>Catalog number:</strong> B2015147_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ¬µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8 ¬∞C_x000D_ <strong>Keywords:</strong> 11 ß-HSD1 CRISPR/Cas9 KO Plasmid_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Akalestou E, Lopez-Noriega L, Christakis I, Hu M, Miras AD, Leclerc I, Rutter GA. Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice Front Endocrinol (Lausanne). 2022 Sep 29;13:1020576._x000D_ 2: Kragl A, Schoon J, Tzvetkova A, Wenzel C, Blaschke M, B√∂cker W, Siggelkow H, Tzvetkov MV. Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells Front Bioeng Biotechnol. 2022 Aug 25;10:953034._x000D_ 3: Brooks K, Burns G, Spencer TE. Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation Biol Reprod. 2015 Aug;93(2):38._x000D_ 4: Zhang Z, Coutinho AE, Man TY, Kipari TMJ, Hadoke PWF, Salter DM, Seckl JR, Chapman KE. Macrophage 11 ß-HSD-1 deficiency promotes inflammatory angiogenesis J Endocrinol. 2017 Sep;234(3):291-299._x000D_ 5: Morgan SA, Tomlinson JW. 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes Expert Opin Investig Drugs. 2010 Sep;19(9):1067-76._x000D_ 6: Masuzaki H, Flier JS. Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):255-62._x000D_ 7: Stimson RH, Walker BR. Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome Minerva Endocrinol. 2007 Sep;32(3):141-59._x000D_ 8: Hughes KA, Webster SP, Walker BR. 11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity Expert Opin Investig Drugs. 2008 Apr;17(4):481-96._x000D_ 9: Mylonas KJ, Turner NA, Bageghni SA, Kenyon CJ, White CI, McGregor K, Kimmitt RA, Sulston R, Kelly V, Walker BR, Porter KE, Chapman KE, Gray GA. 11 ß-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI J Endocrinol. 2017 Jun;233(3):315-327._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/24790006">10: Duan X, Xin H, Yan H. Design, synthesis, and biological evaluation of 1,4-diaryl-1,4-dihydropyrazines as novel 11 ß-HSD1 inhibitors Biol Pharm Bull. 2014;37(5):840-6. </a>_x000D_ _x000D_ <strong>Products Related to 11 ß-HSD1 CRISPR/Cas9 KO Plasmid can be found at</strong> <a href="https://moleculardepot.com/product-category/DNA/"> DNA</a>