Althiomycin

Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated from S. althioticus. It is active against Gram-positive bacteria, including S. aureus, S. epidermidis, and S. pyogenes (MICs=25, 25, and 3.1 μg/mL, respectively) .2 Althiomycin inhibits protein synthesis in E. coli when used at concentrations of 1 and 10 μg/mL but not in isolated rabbit reticulocytes at 100 μg/mL.

Product Specifications

CAS Number

[12656-40-5]

Product Name Alternative

NSC 102809

UNSPSC

12352005

Target

Antibiotic

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/althiomycin.html

Smiles

O=C(C1=CSC(/C=N/O)=N1)NC(C2=N[C@@H](C(N3C(C=C(OC)C3)=O)=O)CS2)CO

Molecular Formula

C16H17N5O6S2

Molecular Weight

439.47

References & Citations

[1]Gerc, et al. The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One 7 (9), e44673 (2012) .