GSK963
GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].
Product Specifications
CAS Number
2049868-46-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/GSK963.html
Concentration
10mM
Purity
99.10
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(C)(C)C(N1N=CC[C@H]1C2=CC=CC=C2)=O
Molecular Formula
C14H18N2O
Molecular Weight
230.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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