Anti-CD2 Antibody

Mouse Monoclonal Antibody specific to CD2

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5, CD antigen CD2

Gene Name

CD2

NCBI Gene ID

UniProt

P06729

Cellular Locus

Cell membrane, Single-pass type I membrane protein

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human CD2.

Target Antigen

T-cell surface antigen CD2

Target

CD2

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

IHC

Field of Research

Cancer research

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Tris

Function

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Additionnal Information

<br><br>Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

Human CD2. Reactivity with other species has not been investigated.

Formulation

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

Buffer pH

pH 7.3-7.7

Target Background

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. The majority of T cell lymphomas and leukemias also express CD2 which makes it possible to distinguish those conditions from B cell neoplasms.