Rabbit anti Human Zinc Finger Protein GLI1
Product Specifications
Background
Zinc Finger Protein GLI1 is a member of the Kruppel family of zinc finger proteins. It is thought that it may regulate the transcription of specific genes during normal development and may play a role in craniofacial development and digital development. It also may be involved in the development of the central nervous system and gastrointestinal tract. This protein mediates SHH signaling and thus cell proliferation and differentiation. It has been localized to the cytoplasm and nucleus. It is tethered in the cytoplasm by binding to SUFU and activation and translocalization to the nucleus is promoted by interation with STK36. Protein expression is amplified in glioblastoma cells. Defects in the GLI1 protein may be a cause of breast cancer.
Synonyms
Glioma-associated oncogene, Oncogene GLI
UniProt
P08151 (Human)
Host
Rabbit
Species Reactivity
Human
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Ammonium Sulfate Precipitation
Assay Principle
Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Kinzler, K.W., et al. 'The GLI gene is a member of the Kruppel family of zinc finger proteins.; Nature 332:371-374(1988).
2. Wang, Z.Q., et al. 'Identification of polymorphic variants of the GLI1 oncogene.; J. Invest. Dermatol. 115:328-329(2000).
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
BNC881686-500 500 µL
Anti-VEGF (Vascular Endothelial Growth Factor)(VG1), CF488A conjugate
Ask
View Details