Human KIR2DL1 / CD158a / NKAT-1 Protein, Fc Tag
Human KIR2DL1, Fc Tag (KI1-H5255) is expressed from human 293 cells (HEK293) . It contains AA His 22 - Arg 242 (Accession # P43626-1) .
Product Specifications
Background
Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors (KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands. Interaction of KIR and HLA is implicated in viral infections, autoimmunity, and reproduction and there is growing evidence of the coevolution of these two independently segregating gene families. Association of KIR2DL1 with β-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated downstream inhibitory signaling.
Specifications
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P43626-1
Expression Region
His 22 - Arg 242
Host
HEK293
Target
KIR2DL1
Conjugation
Unconjugated
Tag
C-Fc
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Bioactivity
Immobilized Human KIR2DL1, Fc Tag (Cat. No. KI1-H5255) at 1 μg/mL (100 μL/well) can bind Lirilummab with a linear range of 0.1-8 ng/mL (QC tested).
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
50.7 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
1mg*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/KI1-H5255.pdf
Species
Human
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