SM-7368

SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].

Product Specifications

CAS Number

[380623-76-7]

Product Name Alternative

2'-3'-cyclic GMP-AMP (sodium),2'-3'-cyclic GMP-AMP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MMP; NF-κB; p38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sm-7368.html

Purity

99.77

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=C(C=CC(C(NC2=NC=C(S2)[N+]([O-])=O)=O)=C1)[N+]([O-])=O

Molecular Formula

C10H5ClN4O5S

Molecular Weight

328.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54 (10) :1458-67.|[2]Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336 (2) :716-22.