Mibefradil (dihydrochloride)
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively) [1].
Product Specifications
CAS Number
116666-63-8
Product Name Alternative
Ro 40-5967 (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Mibefradil-dihydrochloride.html
Purity
99.71
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 150 mg/mL (ultrasonic)
Smiles
O=C(O[C@@]1(CCN(CCCC2=NC3=CC=CC=C3N2)C)[C@@H](C(C)C)C4=C(C=C(F)C=C4)CC1)COC.[H]Cl.[H]Cl
Molecular Formula
C29H40Cl2FN3O3
Molecular Weight
568.55
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
L-type calcium channel; T-type calcium channel
Citation 01
Available Sizes
Frequently Asked Questions
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