Thalidomide-piperidine-O-azetidine-boc

Thalidomide-piperidine-O-azetidine-boc is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

Product Specifications

CAS Number

[2991611-55-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-piperidine-o-azetidine-boc.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CC(C1)OC2CCN(CC2)C3=CC=C4C(N(C5C(NC(CC5)=O)=O)C(C4=C3)=O)=O)OC(C)(C)C

Molecular Formula

C26H32N4O7

Molecular Weight

512.55

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]